This was the second successful permanent English colony in the part of North America that later became the United States, after the Jamestown Colony.
The event known as the "First Thanksgiving" was celebrated by the Pilgrims after their first harvest in the New World which lasted for three days.
Alternatively, Massachusett has been represented as Moswetuset—from the name of the Moswetuset Hummock (meaning "hill shaped like an arrowhead") in Quincy, where Plymouth Colony commander Myles Standish, hired English military officer, and Squanto, part of the now disappeared Patuxet band of the Wampanoag peoples, met Chief Chickatawbut in 1621.
In the early 1600s, after contact had been made with Europeans, large numbers of the indigenous peoples in the northeast of what is now the United States were killed by virgin soil epidemics such as smallpox, measles, influenza, and perhaps leptospirosis.
Harvard University in Cambridge is the oldest institution of higher learning in the United States, Kendall Square in Cambridge has been called "the most innovative square mile on the planet", in reference to the high concentration of entrepreneurial start-ups and quality of innovation which have emerged in the vicinity of the square since 2010.