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It offers best practice advice on managing epilepsy to improve health outcomes so that people with epilepsy can fully participate in daily life MHRA advice on valproate: In February 2016, we updated this guideline to link to the Medicines and Healthcare products Regulatory Agency’s (MHRA) toolkit to ensure female patients are better informed about the risks of taking valproate during pregnancy.

This guideline includes recommendations on: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available.

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